Follicular Helper T (Tfh) Cells in Autoimmune Diseases and Allograft Rejection
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چکیده
منابع مشابه
Follicular Helper T (Tfh) Cells in Autoimmune Diseases and Allograft Rejection
Production of high affinity antibodies for antigens is a critical component for the immune system to fight off infectious pathogens. However, it could be detrimental to our body when the antigens that B cells recognize are of self-origin. Follicular helper T, or Tfh, cells are required for the generation of germinal center reactions, where high affinity antibody-producing B cells and memory B c...
متن کاملFollicular helper T cells in autoimmune diseases.
Complete List of Authors: Papp, Gábor; University of Debrecen Medical Center, Institute of Medicine, Department of Clinical Immunology Szabó, Krisztina; University of Debrecen Medical Center, Institute of Medicine, Department of Clinical Immunology Szekanecz, Zoltán; University of Debrecen Medical Center, Institute of Medicine, Department of Rheumatology Zeher, Margit; University of Debrecen Me...
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BACKGROUND Chronic antibody-mediated rejection is a major issue that affects long-term renal allograft survival. Since follicular helper T (Tfh) cells promote the development of antigen-specific B cells in alloimmune responses, we investigated the potential roles of Tfh cells, B cells and their alloimmune-regulating molecules in the pathogenesis of chronic renal allograft rejection in this stud...
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The pathogenesis of bullous pemphigoid (BP) is characterized by the T cell-dependent production of autoantibodies. Recent studies have indicated that follicular T helper cells (Tfh), the key modulator of B cell activation and autoantibody production, are critical in the development of several autoimmune diseases. Tfh cells perform their functions via IL-21, their hallmark cytokine. In the prese...
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CD4(+)T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides help for germinal center (GC) formation, B-cell development and affinity maturation, and immunoglobulin class switching, as an indispensable part of adaptive immunity. Tfh cell differentiation depends on various factors including cell-surface molecule interactions, extracellular cytokines and multip...
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ژورنال
عنوان ژورنال: Immune Network
سال: 2016
ISSN: 1598-2629,2092-6685
DOI: 10.4110/in.2016.16.4.219